The Contractors shall serve as a Principle Investigator in support of the Bacteriology Division at Ft. Detrick. He/She will conduct basic and applied research on specified bacterial threats, in support of the biodefense and infectious disease program. The Principle investigator will be working in BSL-3 and BSL-4 laboratories and thus must hold and maintain BPRP status, IAW the provisions in this contract and applicable regulations.
Specific Tasks include:
Contractor shall present research findings/presentations at lab meetings and scientific meetings.
Contractor shall prepare supporting author scientific papers for publication.
Contractor shall complete quarterly reports and annual progress reports for DTRA per investigator
Contractor shall conduct transcriptome analyses to better understand bacterial pathogenesis and design vaccines and therapeutics.
Contractor shall create genetic knockouts in Francisella tularensis and Bacillus anthracis for vaccine studies per year.
Contractor shall perform MSD protein assays,PCR, ELISA.
Contractor shall prepare DNA/RNA from bacteria and tissues.
Contractor may mentor high school students.
Contractor shall prepare BSL2, BSL3 labs for Safety, Bio-surety and CDC inspections.
Contractor shall run approximately 100 ELISA tests to support anthrax vaccine studies.
Contractor shall write, plan and execute animal protocols to evaluate experimental anthrax vaccines.
Contractor shall prepare cultures of B. anthracis for vaccine studies in BSL-3 containment.
Contractor will prepare spores for animal challenges for analysis of animal immune response to vaccine.
Contractor shall complete bacterial opsonization assays to evaluate experimental anthrax vaccines.
Contractor shall conduct Equipment Inventory Management twice a year in BSL-2 and BSL-3.
Contractor shall perform monthly Laboratory Management to include safety functions and chemical inventory.
PhD in microbiology or related discipline.
8-10 years of related experience in scientific research and analysis.
Experience working in high containment laboratories.
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